Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1998-11-18
pubmed:abstractText
The mechanism by which early lymphoid cells are selectively transformed by v-Abl is currently unknown. Previous studies have shown constitutive activation of IL-4 and IL-7 signaling pathways, as measured by activation of Janus protein kinase (JAK)1, JAK3, STAT5, and STAT6, in pre-B cells transformed by v-Abl. To determine whether activation of these cytokine signaling pathways by v-Abl is important in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and IL-7 on pre-B cells transformed with a temperature-sensitive v-Abl mutant were examined. Whereas IL-4 had little or no effect, IL-7 delayed both the apoptosis and cell cycle arrest that occur upon v-Abl kinase inactivation. IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity. IL-7 did not maintain v-Abl-mediated differentiation arrest of the pre-B cells, as activation of NF-kappaB and RAG gene transcription was unaffected by IL-7. These results identify a potential role for IL-7 signaling pathways in transformation by v-Abl while demonstrating that a combination of IL-4 and IL-7 signaling cannot substitute for an active v-Abl kinase in transformed pre-B cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/BCL2L1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Bcl2l1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7, http://linkedlifedata.com/resource/pubmed/chemical/JAK1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/JAK3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Jak1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Jak3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins v-abl, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2, http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein, http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/STAT6 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4611-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9794389-Abelson murine leukemia virus, pubmed-meshheading:9794389-Animals, pubmed-meshheading:9794389-Apoptosis, pubmed-meshheading:9794389-B-Lymphocytes, pubmed-meshheading:9794389-Cell Cycle, pubmed-meshheading:9794389-Cell Transformation, Viral, pubmed-meshheading:9794389-Cytokines, pubmed-meshheading:9794389-DNA-Binding Proteins, pubmed-meshheading:9794389-Gene Expression Regulation, Viral, pubmed-meshheading:9794389-Genes, abl, pubmed-meshheading:9794389-Genes, bcl-2, pubmed-meshheading:9794389-Homeodomain Proteins, pubmed-meshheading:9794389-Humans, pubmed-meshheading:9794389-Interleukin-4, pubmed-meshheading:9794389-Interleukin-7, pubmed-meshheading:9794389-Janus Kinase 1, pubmed-meshheading:9794389-Janus Kinase 3, pubmed-meshheading:9794389-Mice, pubmed-meshheading:9794389-Milk Proteins, pubmed-meshheading:9794389-NF-kappa B, pubmed-meshheading:9794389-Oncogene Proteins v-abl, pubmed-meshheading:9794389-Protein-Tyrosine Kinases, pubmed-meshheading:9794389-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:9794389-STAT5 Transcription Factor, pubmed-meshheading:9794389-STAT6 Transcription Factor, pubmed-meshheading:9794389-Signal Transduction, pubmed-meshheading:9794389-Trans-Activators, pubmed-meshheading:9794389-Transcription Factors, pubmed-meshheading:9794389-bcl-X Protein
pubmed:year
1998
pubmed:articleTitle
IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.
pubmed:affiliation
Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't