| pubmed-article:9794233 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9794233 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:9794233 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9794233 | lifeskim:mentions | umls-concept:C0694888 | lld:lifeskim |
| pubmed-article:9794233 | lifeskim:mentions | umls-concept:C0796357 | lld:lifeskim |
| pubmed-article:9794233 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9794233 | pubmed:dateCreated | 1998-11-12 | lld:pubmed |
| pubmed-article:9794233 | pubmed:abstractText | We studied PTEN/MMAC1, a newly discovered candidate tumor suppressor gene at 10q23.3, for mutations in lung cancer. One hundred and thirty-six lung cancer cell line DNAs (66 small cell lung cancers, SCLC, 61 non-small cell lung cancers, NSCLC, four mesotheliomas, five extrapulmonary small cell cancers) were analysed for PTEN/MMAC1 homozygous deletions and five (8%) SCLC lines showed homozygous deletions interrupting the PTEN/MMAC1 gene. Using single stranded conformation polymorphism (SSCP) analysis, we screened the PTEN/MMAC1 open reading frame of 53 lung cancer cell line cDNAs for point mutations and found that 3/35 SCLCs and 3/18 NSCLCs contained homozygous amino acid sequence altering mutations. Northern blot analysis revealed that expression of the PTEN/MMAC1 gene was considerably lower in all the tumor cell lines with point mutations while no expression was detected for cell lines with PTEN/MMAC1 homozygous deletions. Mutation analysis of 22 uncultured, microdissected, primary SCLC tumors and metastases showed two silent mutations, and two apparent homozygous deletions. We also discovered a processed pseudogene (PTEN2) which has 98.5% nt identity to PTEN/MMAC1, that needs to be accounted for in cDNA mutation analysis. Our findings suggest that genetic abnormalities of the PTEN/MMAC1 gene are only involved in a relatively small subset of lung cancers. | lld:pubmed |
| pubmed-article:9794233 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9794233 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9794233 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9794233 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9794233 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9794233 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:GazdarA FAF | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:MinnaJ DJD | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:FongKK | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:MilchgrubSS | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:BrezinschekRR | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:SekidoYY | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:VirmaniAA | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:WistubaI III | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:ForgacsEE | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:BiesterveldE... | lld:pubmed |
| pubmed-article:9794233 | pubmed:author | pubmed-author:MuneerSS | lld:pubmed |
| pubmed-article:9794233 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9794233 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9794233 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9794233 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9794233 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9794233 | pubmed:pagination | 1557-65 | lld:pubmed |
| pubmed-article:9794233 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9794233 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9794233 | pubmed:articleTitle | Mutation analysis of the PTEN/MMAC1 gene in lung cancer. | lld:pubmed |
| pubmed-article:9794233 | pubmed:affiliation | Hamon Center for Therapeutic Oncology Research, University of Texas, Southwestern Medical Center, Dallas 75235, USA. | lld:pubmed |
| pubmed-article:9794233 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9794233 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9794233 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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