9794102

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004083, umls-concept:C0008059, umls-concept:C0032854, umls-concept:C0043094, umls-concept:C0178665, umls-concept:C0439831, umls-concept:C0687676, umls-concept:C1561558
pubmed:issue	10
pubmed:dateCreated	1999-1-14
pubmed:abstractText	A number of studies have shown that glucose tolerance falls with decreasing birth weight and that people with low birth weight and high body mass index (BMI) as adults are those at greatest risk of developing Type II (non-insulin-dependent) diabetes mellitus. No such studies have been carried out in African populations. Therefore we investigated the relation between glucose tolerance and birth weight in a group of 7-year-old black South Africans for whom longitudinal anthropometric data were available. Oral glucose tolerance tests (OGTTs) were carried out on 152 subjects and inverse correlations were found between birth weight and the total amount of insulin secreted during the first 30 min (r = -0.19, p = 0.04) and last 90 min (r = -0.19, p = 0.04) of the oral glucose tolerance test and also between birth weight and the 30 min glucose concentrations (r = -0.20, p = 0.02). Children born with low birth weights but who had high weights at 7 years had higher insulin concentrations and indices of obesity compared with those with low birth weights and low weights at 7 years. There were also positive correlations between weight velocity and BMI (r = 0.24, p = 0.02) and weight velocity and insulin resistance (r = 0.18, p = 0.04) as measured using homeostasis model assessment (HOMA). Thus, low birth weight in conjunction with rapid childhood gains in weight especially as subcutaneous fat, produces poor glucose tolerance in 7-year-old children and can make them susceptible to the development of Type II diabetes later in life.
pubmed:keyword	http://linkedlifedata.com/resource/pubmed/keyword/ADULT, http://linkedlifedata.com/resource/pubmed/keyword/Africa, http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara, http://linkedlifedata.com/resource/pubmed/keyword/Age Factors, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Birth Weight, http://linkedlifedata.com/resource/pubmed/keyword/Body Weight, http://linkedlifedata.com/resource/pubmed/keyword/CHILD, http://linkedlifedata.com/resource/pubmed/keyword/Carbohydrate Metabolic Effects, http://linkedlifedata.com/resource/pubmed/keyword/DIABETES MELLITUS, http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors, http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/English Speaking Africa, http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses, http://linkedlifedata.com/resource/pubmed/keyword/GLUCOSE TOLERANCE TEST, http://linkedlifedata.com/resource/pubmed/keyword/Glucose Metabolism Effects, http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses, http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures, http://linkedlifedata.com/resource/pubmed/keyword/Low Birth Weight, http://linkedlifedata.com/resource/pubmed/keyword/Metabolic Effects, http://linkedlifedata.com/resource/pubmed/keyword/OBESITY, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Population, http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics, http://linkedlifedata.com/resource/pubmed/keyword/Research Report, http://linkedlifedata.com/resource/pubmed/keyword/Risk Factors, http://linkedlifedata.com/resource/pubmed/keyword/SOUTH AFRICA, http://linkedlifedata.com/resource/pubmed/keyword/Southern Africa, http://linkedlifedata.com/resource/pubmed/keyword/Youth
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0006777
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Insulin
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0012-186X
pubmed:author	pubmed-author:CameronNN, pubmed-author:CrowtherN JNJ, pubmed-author:GrayI PIP, pubmed-author:TruslerJJ
pubmed:issnType	Print
pubmed:volume	41
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1163-7
pubmed:dateRevised	2011-11-17
pubmed:otherAbstract	PIP: A number of studies have shown that glucose tolerance declines with decreasing birth weight and that people with low birth weight and high body mass index (BMI) as adults are at the highest risk of developing type II (non-insulin-dependent) diabetes mellitus. The authors explored the relation between glucose tolerance and birth weight in a group of 7-year old Black South Africans for whom longitudinal anthropometric data were available. Oral glucose tolerance tests (OGTTs) were conducted on 152 subjects and inverse correlations were found between birth weight and the total amount of insulin secreted during the first 30 minutes and last 90 minutes of the oral glucose tolerance test, and also between birth weight and the 30 minute glucose concentrations. Children born with low birth weights, but who had high weights at age 7 years had higher insulin concentrations and indices of obesity compared with those with low birth weights and low weights at age 7 years. Positive correlations were also found between weight velocity and BMI, and weight velocity and insulin resistance as measured through homeostasis model assessment. Therefore, low birth weight together with rapid childhood weight gains, especially in subcutaneous fat, produces poor glucose tolerance in 7-year old children and can make them susceptible to the development of type II diabetes later in life.
pubmed:meshHeading	pubmed-meshheading:9794102-African Continental Ancestry Group, pubmed-meshheading:9794102-Birth Weight, pubmed-meshheading:9794102-Body Mass Index, pubmed-meshheading:9794102-Child, pubmed-meshheading:9794102-Cohort Studies, pubmed-meshheading:9794102-Diabetes Mellitus, Type 2, pubmed-meshheading:9794102-Female, pubmed-meshheading:9794102-Glucose Tolerance Test, pubmed-meshheading:9794102-Humans, pubmed-meshheading:9794102-Infant, Low Birth Weight, pubmed-meshheading:9794102-Infant, Newborn, pubmed-meshheading:9794102-Insulin, pubmed-meshheading:9794102-Insulin Resistance, pubmed-meshheading:9794102-Longitudinal Studies, pubmed-meshheading:9794102-Male, pubmed-meshheading:9794102-Obesity, pubmed-meshheading:9794102-Risk Factors, pubmed-meshheading:9794102-Skinfold Thickness, pubmed-meshheading:9794102-South Africa, pubmed-meshheading:9794102-Weight Gain
pubmed:year	1998
pubmed:articleTitle	Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children.
pubmed:affiliation	Department of Chemical Pathology, South African Institute for Medical Research, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't