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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1998-11-3
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pubmed:abstractText |
The goal of chemoprevention is to reduce the risk of cancer development by reversing or blocking the tumorigenic process through the use of pharmacologic or natural agents. To determine the potential role of genetic alterations in assessing cancer risk and in evaluating the efficacy of chemopreventive agents, we studied 22 patients with advanced premalignant lesions of the head and neck who were part of a prospective cancer prevention trial that is investigating a regimen of 13-cis-retinoic acid, interferon alfa, and alpha-tocopherol administered for 12 months or until disease progression.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8874
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pubmed:author |
pubmed-author:ClaymanGG,
pubmed-author:El-NaggarA KAK,
pubmed-author:FayTT,
pubmed-author:HittelmanW NWN,
pubmed-author:HopeW GWG,
pubmed-author:LeeJ JJJ,
pubmed-author:LeeJ SJS,
pubmed-author:LippmanS MSM,
pubmed-author:ManMM,
pubmed-author:PapadimitrakopoulouVV,
pubmed-author:ShinD MDM,
pubmed-author:ShinH CHC,
pubmed-author:ZhouXX
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1545-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9790547-Antineoplastic Agents,
pubmed-meshheading:9790547-Chromosomes, Human, Pair 9,
pubmed-meshheading:9790547-DNA, Neoplasm,
pubmed-meshheading:9790547-Female,
pubmed-meshheading:9790547-Genotype,
pubmed-meshheading:9790547-Head and Neck Neoplasms,
pubmed-meshheading:9790547-Humans,
pubmed-meshheading:9790547-Interferon-alpha,
pubmed-meshheading:9790547-Isotretinoin,
pubmed-meshheading:9790547-Loss of Heterozygosity,
pubmed-meshheading:9790547-Male,
pubmed-meshheading:9790547-Microsatellite Repeats,
pubmed-meshheading:9790547-Phenotype,
pubmed-meshheading:9790547-Polymerase Chain Reaction,
pubmed-meshheading:9790547-Precancerous Conditions,
pubmed-meshheading:9790547-Prospective Studies,
pubmed-meshheading:9790547-Vitamin E
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pubmed:year |
1998
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pubmed:articleTitle |
Phenotype and genotype of advanced premalignant head and neck lesions after chemopreventive therapy.
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pubmed:affiliation |
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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