Linked Life Data

9785474

Source:http://linkedlifedata.com/resource/pubmed/id/9785474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1998-11-18
pubmed:abstractText
Follistatin, a secreted protein is able to bind and neutralise the actions of many members of the Transforming Growth Factor-beta family of proteins. Follistatin was first implicated in the regulation of follicle-stimulating hormone secretion in the pituitary and subsequently in other regions of the adult body associated with reproductive functions. Recent work has shown that this protein is much more broadly distributed and may also play a significant role during embryogenesis. Gene targetting has shown that follistatin is essential for normal development and in its absence, mice die soon after birth with a range of defects including insufficient muscle development and skeletal abnormalities. A number of diseases have been identified thought to be caused by an over-production of members of the Transforming Growth Factor-beta family of proteins. Therefore it may be possible to use follistatin as a therapeutic agent in these disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1357-2725
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1087-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Follistatin.
pubmed:affiliation
Department of Zoology, Animal and Microbial Sciences, University of Reading, Whiteknights, UK. k.patel@reading.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't