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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
3
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|
pubmed:dateCreated |
1976-12-23
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|
pubmed:abstractText |
We have examined the effects of six tryptolines (tetrahydro-beta-carbolines) upon 5-hydroxytryptamine (5-HT) uptake into rat forebrain homogenates. All six were found to be competitive inhibitors of 5-HT uptake. 5-Hydroxytryptoline, the most potent inhibitor, had an inhibitor constant (Ki) of 0.3 mugM. Both 5-hydroxytryptoline and 5-hydroxymethtryptoline were also shown to be relatively selective against 5-HT uptake, being 20 times less potent against norepinephrine uptake and 40 times less potent against dopamine. Since it is possible that tryptolines might be formed as a result of alcohol consumption, these results suggest that it is important to examine the possibilities that such compounds mediate some of the effects of alcohol upon serotonergic pathways.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3565
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
198
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
619-25
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pubmed:dateRevised |
2009-10-27
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pubmed:meshHeading |
pubmed-meshheading:978463-Alcohol Drinking,
pubmed-meshheading:978463-Animals,
pubmed-meshheading:978463-Brain,
pubmed-meshheading:978463-Carbolines,
pubmed-meshheading:978463-Dopamine,
pubmed-meshheading:978463-Indoles,
pubmed-meshheading:978463-Male,
pubmed-meshheading:978463-Norepinephrine,
pubmed-meshheading:978463-Phenyl Ethers,
pubmed-meshheading:978463-Propylamines,
pubmed-meshheading:978463-Rats,
pubmed-meshheading:978463-Serotonin
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pubmed:year |
1976
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|
pubmed:articleTitle |
Tryptoline inhibition of serotonin uptake in rat forebrain homogenates.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.
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