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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-11-25
|
| pubmed:abstractText |
Reproductive, including developmental, toxicity risk assessment has typically relied on estimation of toxicity criteria values derived from no-observed-adverse-effect levels (NOAELs). The benchmark dose (BMD) approach has been proposed as an alternative that avoids problems with NOAELs. In this analysis of the reproductive and developmental toxicity observed in a multigeneration study of rats exposed to isopropanol, the BMD approach has been applied to all effects exhibiting significant dose-response relationships. The BMD estimates were very consistent across models and across end points; they were within the range of doses (100 to 500 mg/kg/day) that has been suggested as being the NOAEL. The use of the BMD approach for analysis of isopropanol reproductive toxicity is shown to avoid the experiment-specific argument of whether a particular treatment has induced statistically significant differences, compared to controls, in favor of the estimation of experiment-independent doses corresponding to risk levels of interest. The consistency of the BMD estimates, with values of about 420 mg/kg/day, suggests that, for isopropanol, the available multigeneration study data may provide a suitable basis for considering safe exposure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0273-2300
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Academic Press.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
38-44
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:9784431-2-Propanol,
pubmed-meshheading:9784431-Animals,
pubmed-meshheading:9784431-Animals, Newborn,
pubmed-meshheading:9784431-Dose-Response Relationship, Drug,
pubmed-meshheading:9784431-Embryonic and Fetal Development,
pubmed-meshheading:9784431-Female,
pubmed-meshheading:9784431-Fertility,
pubmed-meshheading:9784431-Infertility, Male,
pubmed-meshheading:9784431-Litter Size,
pubmed-meshheading:9784431-Male,
pubmed-meshheading:9784431-Models, Biological,
pubmed-meshheading:9784431-No-Observed-Adverse-Effect Level,
pubmed-meshheading:9784431-Pregnancy,
pubmed-meshheading:9784431-Rats,
pubmed-meshheading:9784431-Risk Assessment,
pubmed-meshheading:9784431-Sexual Behavior, Animal,
pubmed-meshheading:9784431-Solvents,
pubmed-meshheading:9784431-Survival Rate
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Calculation of benchmark doses for reproductive and developmental toxicity observed after exposure to isopropanol.
|
| pubmed:affiliation |
The K. S. Crump Group, Inc., ICF Kaiser, 602 East Georgia, Ruston, Louisiana 71270, USA.
|
| pubmed:publicationType |
Journal Article
|