Linked Life Data

9783671

Source:http://linkedlifedata.com/resource/pubmed/id/9783671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-12-30
pubmed:abstractText
The monoclonal antibody-specific immobilization of platelet antigens (MAIPA) assay is considered as a possible reference method for the detection of maternal alloantibodies when a foetomaternal alloimmunization is suspected. However, this method is tedious. In this study, we have compared the MAIPA results of 54 samples of mothers with (n=34) or without (n=20) alloantibodies with those obtained with a new antigen capture ELISA. Using the cutoff of 2.0 given by the manufacturer, the new kit had a sensitivity of 88.2% (95% CI 72.6-96.7) and a specificity of 100% (95% CI 98.0-100). From a receiver-operating characteristic curve analysis, the more appropriate cutoff for a screening assay would be 1.6, which gives a sensitivity of 100% (95% CI 89.7-100) with a specificity of 94.0% (95% CI 89.4-96.9). In conclusion, this new simple assay appears promising and could be used, with the modified cutoff, as a screening assay for the detection of platelet alloantibodies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0049-3848
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Evaluation of a new antigen capture ELISA for detection and characterization of platelet alloantibodies.
pubmed:affiliation
Medical Clinics II, Department of Medicine, University Hospital, Geneva, Switzerland.
pubmed:publicationType
Journal Article, Comparative Study