rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-10-27
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pubmed:abstractText |
The heritability of interindividual variation in anxiety and other aspects of personality establishes that variants of genes influence these traits. A functional polymorphism in the promoter of the human serotonin transporter gene (SLC6A4*C) was identified and found to be linked to an anxiety-related personality trait, Neuroticism. The polymorphism affects gene transcription and, ultimately, gene function. We have attempted to confirm the role of SLC6A4*C in anxiety-related personality traits by sibpair analysis and association studies.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-990X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
936-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9783565-Alcoholism,
pubmed-meshheading:9783565-Anxiety,
pubmed-meshheading:9783565-Carrier Proteins,
pubmed-meshheading:9783565-Crime,
pubmed-meshheading:9783565-Genetic Linkage,
pubmed-meshheading:9783565-Humans,
pubmed-meshheading:9783565-Membrane Glycoproteins,
pubmed-meshheading:9783565-Membrane Transport Proteins,
pubmed-meshheading:9783565-Nerve Tissue Proteins,
pubmed-meshheading:9783565-Personality,
pubmed-meshheading:9783565-Polymerase Chain Reaction,
pubmed-meshheading:9783565-Polymorphism, Genetic,
pubmed-meshheading:9783565-Promoter Regions, Genetic,
pubmed-meshheading:9783565-Serotonin,
pubmed-meshheading:9783565-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:9783565-Transcription, Genetic
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pubmed:year |
1998
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pubmed:articleTitle |
Role of the serotonin transporter promoter polymorphism in anxiety-related traits.
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pubmed:affiliation |
Laboratory of Neurogenetics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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