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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1998-11-19
|
| pubmed:abstractText |
Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0019-5189
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
675-9
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9782784-Administration, Oral,
pubmed-meshheading:9782784-Animals,
pubmed-meshheading:9782784-Condiments,
pubmed-meshheading:9782784-Curcuma,
pubmed-meshheading:9782784-Drug-Induced Liver Injury,
pubmed-meshheading:9782784-Female,
pubmed-meshheading:9782784-Mice,
pubmed-meshheading:9782784-Microscopy, Electron,
pubmed-meshheading:9782784-Plant Extracts
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies.
|
| pubmed:affiliation |
Cell Biology Division, Tata Memorial Centre, Mumbai, India.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|