Linked Life Data

9780090

Source:http://linkedlifedata.com/resource/pubmed/id/9780090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-6-7
pubmed:abstractText
It is generally assumed that the majority of substance P (SP)-containing afferents are also immunoreactive for calcitonin gene-related peptide (CGRP). In order to determine whether this is also the case in articular afferents where the contents of these peptides are low, we carried out a double labeling study using Fast Blue (FB) as a retrograde tracer injected into the center of the knee joint cavity of the dog together with immunohistochemistry for SP and CGRP. After 7-36 days of survival, dorsal root ganglia (DRGs, L4-S1) were removed. Labeled cells were found mainly (94%) in L5 - 6 DRGs, and SP- and CGRP-like immunoreactivity was found in about 17 and 29% of FB-labeled cells, respectively. The coexistence of SP and CGRP was observed in 10.4% of articular afferents and only 62.7% of SP-positive articular neurons contained CGRP, a much lower ratio than in other afferents of the dog such as testicular afferents. Our data suggest that these peptides are not always released together and that they do not always work together in the joint under normal conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Examination of colocalization of calcitonin gene-related peptide- and substance P-like immunoreactivity in the knee joint of the dog.
pubmed:affiliation
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Japan.
pubmed:publicationType
Journal Article