Linked Life Data

9780085

Source:http://linkedlifedata.com/resource/pubmed/id/9780085

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-6-7
pubmed:abstractText
Lesioned afferents were tested for their responses to blockade of nitric oxide synthesis in the spinal nerve L5 lesion model for neuropathic pain in Wistar rats. Seven single fibers with spontaneous activity split from dorsal root L5 showed no response after non-selective blockade of nitric oxide synthesis with N(G)-nitro-L-arginine methyl ester whereas five were excited after 5-7 min. Three previously silent units were recruited. Blood flow in the dorsal root ganglion decreased. None of fifteen axotomized afferents tested responded to selective blockade of neuronal nitric oxide synthesis with 7-nitroindazole. It is concluded that neuronal nitric oxide is not involved in the generation of spontaneous activity in axotomized afferent neurons in this model. We suggest that the vasoconstriction induced by blockade of endothelial nitric oxide may be responsible for the excitatory responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Responses of axotomized afferents to blockade of nitric oxide synthesis after spinal nerve lesion in the rat.
pubmed:affiliation
Physiologisches Institut, Christian-Albrechts-Universität, Kiel, Germany. j.haebler@physiologie.uni-kiel.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't