Linked Life Data

9778704

Source:http://linkedlifedata.com/resource/pubmed/id/9778704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1998-11-30
pubmed:abstractText
The aim of the study was to quantify the influence of both contact lens material and replacement frequency on protein and lipid deposition. The following hypotheses were tested: (1) both protein and lipid interaction with contact lenses are material-dependent, and (2) the key factors are the material ionicity for the protein deposition and the material chemical composition for the lipid deposition. Three high water content contact lens materials were tested: netrafilcon A (FDA group II, Gentle Touch), etafilcon A (FDA group IV, Acuvue), and vifilcon A (FDA group IV, Focus). Contact lens spoilation was analyzed using ultraviolet spectroscopy and fluorescence spectrophotometry. The results showed that (1) significantly more proteins were deposited on the ionic materials than on the nonionic materials, and that among the ionic materials, the higher the ionicity, the higher the level of protein deposition; (2) there were significantly more surface proteins on the ionic materials after 3 months than after 1 month of wear, but no difference over time was demonstrated for the nonionic materials; and (3) significantly more lipids were deposited onto the surface of vifilcon A than etafilcon A or netrafilcon A, and the presence of vinylpyrrolidone in the vifilcon A formulation was thought to be the cause of increased deposition. The protein and lipid interactions with contact lenses were found to be material- and time-dependent. Protein attraction was found to be related to the material ionicity. The presence of vinylpyrrolidone was a key factor in the attraction of lipids.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1040-5488
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
697-705
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Influence of contact lens material surface characteristics and replacement frequency on protein and lipid deposition.
pubmed:affiliation
Aston Biomaterials Research Unit, CEAC, Aston University, Birmingham, United Kingdom.
pubmed:publicationType
Journal Article