Linked Life Data

9776249

Source:http://linkedlifedata.com/resource/pubmed/id/9776249

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-12-22
pubmed:abstractText
Optimal transformation efficiencies or tumour formation in certain target tissues require the SV40 small-t antigen in addition to the transforming protein, large-T. We have used two model systems in which small-t is required for transformation to roles of individual viral proteins in this process. These systems include anchorage-independent growth of rat fibroblasts and focus formation by primary human diploid fibroblasts. In both cases, large-T and small-t antigens work together to drive cell cycle induction. Thus, the need for both tumour antigens is apparent in the initial step of the transformation process, the stimulation of quiescent cells to enter the cell cycle.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-95
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Small-t and large-T antigens cooperate to drive cell proliferation.
pubmed:affiliation
Northwestern University, Department of Microbiology-Immunology and The Lurie Cancer Center, Chicago, IL 60611, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't