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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-12-17
|
| pubmed:abstractText |
The parasitological, clinical efficacy and tolerability of albendazole in the treatment for both giardiasis and hookworm infection in a remote Aboriginal population was investigated. Albendazole at a dose rate of 400 mg daily for 5 days was highly effective in reducing hookworm egg numbers and both Giardia antigen and cysts. The 36.6% prevalence of Giardia prior to treatment fell to 12% between days 6 and 9, 15% for days 10-17 and rose to 28% between days 18 and 30. Tolerability and clinical efficacy were excellent. The effect of albendazole on hookworm was longer lasting than that on Giardia, reducing percent infection from over 76-2% on days 6-9 and zero by day 18-30 despite conditions highly conducive to rapid re-infection. We conclude that albendazole is highly efficacious against both parasites when used as described but that long term community benefit may require additional education programmes to avoid re-infection with Giardia although treatment strategies would seem appropriate for hookworm.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0001-706X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
27-44
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9776141-Adolescent,
pubmed-meshheading:9776141-Adult,
pubmed-meshheading:9776141-Age Factors,
pubmed-meshheading:9776141-Aged,
pubmed-meshheading:9776141-Albendazole,
pubmed-meshheading:9776141-Ancylostoma,
pubmed-meshheading:9776141-Animals,
pubmed-meshheading:9776141-Anthelmintics,
pubmed-meshheading:9776141-Antigens, Helminth,
pubmed-meshheading:9776141-Antigens, Protozoan,
pubmed-meshheading:9776141-Child,
pubmed-meshheading:9776141-Child, Preschool,
pubmed-meshheading:9776141-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9776141-Feces,
pubmed-meshheading:9776141-Female,
pubmed-meshheading:9776141-Giardia,
pubmed-meshheading:9776141-Giardiasis,
pubmed-meshheading:9776141-Hookworm Infections,
pubmed-meshheading:9776141-Humans,
pubmed-meshheading:9776141-Male,
pubmed-meshheading:9776141-Middle Aged,
pubmed-meshheading:9776141-Oceanic Ancestry Group,
pubmed-meshheading:9776141-Parasite Egg Count,
pubmed-meshheading:9776141-Prevalence,
pubmed-meshheading:9776141-Sex Factors,
pubmed-meshheading:9776141-Statistics, Nonparametric,
pubmed-meshheading:9776141-Western Australia
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia.
|
| pubmed:affiliation |
Division of Veterinary and Biomedical Sciences, Murdoch University, Western Australia, Australia. reynolds@numbat.murdoch.edu.au
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|