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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-11-2
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pubmed:abstractText |
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2 coexist in a biochemical complex and colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes. Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation. Thus, BRCA1 and BRCA2 participate, together, in a pathway(s) associated with the activation of double-strand break repair and/or homologous recombination. Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary breast and/or ovarian cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-2765
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pubmed:author |
pubmed-author:AshleyTT,
pubmed-author:CantorS BSB,
pubmed-author:ChenJJ,
pubmed-author:CouchF JFJ,
pubmed-author:GazdarA FAF,
pubmed-author:LivingstonD MDM,
pubmed-author:ScullyRR,
pubmed-author:SilverD PDP,
pubmed-author:TomlinsonGG,
pubmed-author:WalpitaDD,
pubmed-author:WeberB LBL
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-28
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9774970-Antibodies, Monoclonal,
pubmed-meshheading:9774970-BRCA1 Protein,
pubmed-meshheading:9774970-BRCA2 Protein,
pubmed-meshheading:9774970-Breast Neoplasms,
pubmed-meshheading:9774970-Cell Line,
pubmed-meshheading:9774970-Cell Nucleus,
pubmed-meshheading:9774970-Chromosome Mapping,
pubmed-meshheading:9774970-DNA Damage,
pubmed-meshheading:9774970-DNA Repair,
pubmed-meshheading:9774970-DNA Replication,
pubmed-meshheading:9774970-DNA-Binding Proteins,
pubmed-meshheading:9774970-Female,
pubmed-meshheading:9774970-Genes, BRCA1,
pubmed-meshheading:9774970-Genes, Tumor Suppressor,
pubmed-meshheading:9774970-Humans,
pubmed-meshheading:9774970-Meiosis,
pubmed-meshheading:9774970-Mitosis,
pubmed-meshheading:9774970-Neoplasm Proteins,
pubmed-meshheading:9774970-Ovarian Neoplasms,
pubmed-meshheading:9774970-Rad51 Recombinase,
pubmed-meshheading:9774970-Transcription Factors,
pubmed-meshheading:9774970-Transfection,
pubmed-meshheading:9774970-Tumor Cells, Cultured,
pubmed-meshheading:9774970-Zygote
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pubmed:year |
1998
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pubmed:articleTitle |
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
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pubmed:affiliation |
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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