Linked Life Data

9774604

Source:http://linkedlifedata.com/resource/pubmed/id/9774604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-12-11
pubmed:abstractText
We compared the QUANTIPLEX HIV-1 RNA 2.0 assay with the AMPLICOR HIV-1 MONITOR 1.0 assay for quantitation of human immunodeficiency virus type 1 (HIV-1) RNA in plasma in the Stadi trail, which evaluated a stavudine plus didanosine combination therapy in 52 patients. HIV-1 RNA baseline values measured with AMPLICOR HIV-1 MONITOR 1.0 were significantly higher than those measured with QUANTIPLEX HIV-1 RNA 2.0, and decreases in HIV-1 RNA levels from baseline were also found to be significantly higher when measured with the AMPLICOR HIV-1 MONITOR 1.0 assay. The frequency of HIV-1 RNA levels below the lower limit of quantitation was significantly higher with QUANTIPLEX HIV-1 RNA 2.0 than with AMPLICOR HIV-1 MONITOR 1.0. Reanalysis of these results by an ultrasensitive procedure of AMPLICOR HIV-1 MONITOR 1.0 or by a modified version of the test that included additional primers adapted for non-B HIV-1 clades yielded greater differences between the QUANTIPLEX HIV-1 RNA 2.0 assay and the AMPLICOR HIV-1 MONITOR 1.0 assay. Our results indicate that a valid comparison of the virological efficacies obtained with different antiretroviral drug regimens requires the use of the same viral load quantitation procedure; further standardization between the different HIV-1 RNA quantitation kits is therefore needed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-2298875, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8150937, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8366168, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8638160, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8727875, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8813039, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8843206, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8940441, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8940471, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8950685, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-8964032, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-9016609, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-9114426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-9419168, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-9431977, http://linkedlifedata.com/resource/pubmed/commentcorrection/9774604-9508301
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3392-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Comparison of the QUANTIPLEX HIV-1 RNA 2.0 assay with the AMPLICOR HIV-1 MONITOR 1.0 assay for quantitation of levels of human immunodeficiency virus type 1 RNA in plasma of patients receiving stavudine-didanosine combination therapy.
pubmed:affiliation
Department of Virology and Department of Infectious and Tropical Diseases, Montpellier University Hospital, Montpellier, France. msegondy@worldnet.fr
pubmed:publicationType
Journal Article, Comparative Study