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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-12-29
|
| pubmed:abstractText |
We investigated the influence of restricted maternal nutrition between 28 and 77 d of gestation on placental weight and appearance, and on fetal weight and conformation. Single-bearing ewes were fed either twice [i.e. controls (n = 19)] or half [i.e. nutrient-restricted (n = 28)] their energy requirements from 28 to 77 d of gestation, after which all ewes were fed to fully meet the energy requirements for maintenance and pregnancy. Close to term (145 +/- 1 d) placental weight was higher in the nutrient-restricted group [nutrient-restricted, 416.3 +/- 12.6 g; controls, 347.4 +/- 17.6 g (p < 0.01)], as was the abundance of everted placentomes. There was no significant difference in total fetal weight, or weights of individual organs between groups, but crown-rump length was significantly greater in lambs born to nutrient-restricted ewes [nutrient-restricted, 50.4 +/- 0.4 cm; controls, 48.2 +/- 0.6, cm (p < 0.01)]. Fetal to placental weight ratio was lower in the nutrient-restricted group [nutrient-restricted, 9.51 +/- 0.23; controls, 10.81 +/- 0.39 (p < 0.01)]. A stronger relationship between the total weight of the fetal component of the placental and fetal weight was observed in controls (r2 = 0.50) than in nutrient-restricted ewes (r2 = 0.18). In conclusion, maternal nutrient restriction over the period of rapid placental growth results in a larger placenta and altered placental to fetal weight ratio if ewes are subsequently fed to requirements for the remainder of gestation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0031-3998
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
546-51
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:9773844-Analysis of Variance,
pubmed-meshheading:9773844-Animal Nutritional Physiological Phenomena,
pubmed-meshheading:9773844-Animals,
pubmed-meshheading:9773844-Animals, Newborn,
pubmed-meshheading:9773844-Body Constitution,
pubmed-meshheading:9773844-Body Weight,
pubmed-meshheading:9773844-Embryonic and Fetal Development,
pubmed-meshheading:9773844-Energy Intake,
pubmed-meshheading:9773844-Energy Metabolism,
pubmed-meshheading:9773844-Fatty Acids, Nonesterified,
pubmed-meshheading:9773844-Female,
pubmed-meshheading:9773844-Gestational Age,
pubmed-meshheading:9773844-Nutrition Disorders,
pubmed-meshheading:9773844-Organ Size,
pubmed-meshheading:9773844-Placenta,
pubmed-meshheading:9773844-Pregnancy,
pubmed-meshheading:9773844-Pregnancy Complications,
pubmed-meshheading:9773844-Prenatal Exposure Delayed Effects,
pubmed-meshheading:9773844-Sheep
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Influence of restricted maternal nutrition in early to mid gestation on placental and fetal development at term in sheep.
|
| pubmed:affiliation |
Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|