Linked Life Data

9772691

Source:http://linkedlifedata.com/resource/pubmed/id/9772691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1998-11-13
pubmed:abstractText
The study on structure-activity relationship of saikosaponins and glycyrrhizin derivatives for Na+, K(+)-ATPase inhibiting action has been made in vitro. The results showed that the order of potency of inhibitory effect of saikosaponins on Na+, K(+)-ATPase is as follows: b1 > d > b2 > b4 > a > b3 > e > c. The chemical structure C23-OH, C16-OH and the C11, C13 conjugated double diene of saikosaponins are important for its inhibitory activity. The inhibitory potency of glycyrrhizin (GL), glycyrrhetinic acid (GA) and carbenoxolone (CX) for Na+, K(+)-ATPase activity is as follows: GA > or = CX > GL. In addition, the inhibitory effect of saikosaponin d on Na+, K(+)-ATPase was found to be non-competitive.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0513-4870
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
496-501
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[The structure activity relationship of saikosaponins and glycyrrhizin derivatives for Na+, K(+)-ATPase inhibiting action].
pubmed:affiliation
Institute of Preclinical Sciences, Norman Bethune University of Medical Sciences, Changchun.
pubmed:publicationType
Journal Article, English Abstract