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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1998-11-16
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pubmed:abstractText |
The armadillo gene is a segment polarity gene of Drosophila involved in signal transduction through wingless. Since the mid-1980s, a growing number of related proteins have been identified based on sequence homologies. These proteins share a central domain that is composed of a series of imperfect 45 amino acid repeats. Armadillo family members reveal diverse cellular locations reflecting their diverse functions. A single protein exerts several functions through interactions of its armadillo repeat domain with diverse binding partners. The proteins combine structural roles as cell-contact and cytoskeleton-associated proteins and signaling functions by generating and transducing signals affecting gene expression. The study of armadillo family members has made it increasingly clear that a distinction between structural proteins on the one hand and signaling molecules on the other is rather artificial. Instead armadillo family members exert both functions by interacting with a number of distinct cellular-binding partners.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenomatous Polyposis Coli Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Armadillo Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Desmoplakins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/armadillo protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:issn |
0074-7696
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-224
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9770300-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:9770300-Animals,
pubmed-meshheading:9770300-Armadillo Domain Proteins,
pubmed-meshheading:9770300-Cadherins,
pubmed-meshheading:9770300-Cell Adhesion,
pubmed-meshheading:9770300-Cytoskeletal Proteins,
pubmed-meshheading:9770300-Desmoplakins,
pubmed-meshheading:9770300-Drosophila,
pubmed-meshheading:9770300-Drosophila Proteins,
pubmed-meshheading:9770300-Genes, Insect,
pubmed-meshheading:9770300-Genetic Variation,
pubmed-meshheading:9770300-Humans,
pubmed-meshheading:9770300-Insect Proteins,
pubmed-meshheading:9770300-Neoplasms,
pubmed-meshheading:9770300-Phylogeny,
pubmed-meshheading:9770300-Repetitive Sequences, Amino Acid,
pubmed-meshheading:9770300-Signal Transduction,
pubmed-meshheading:9770300-Trans-Activators,
pubmed-meshheading:9770300-Transcription Factors,
pubmed-meshheading:9770300-beta Catenin
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pubmed:year |
1999
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pubmed:articleTitle |
The armadillo family of structural proteins.
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pubmed:affiliation |
Molecular Biology Group, Medical Faculty, University of Halle, Germany.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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