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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-12-8
|
| pubmed:abstractText |
Although 10%-15% of patients with AIDS in the United States may acquire cryptosporidium infection, little data exist on clinical or histological characteristics that differentiate clinical outcomes. A case-control study of 83 HIV-positive adult patients with cryptosporidiosis was conducted, as was a histopathologic review of data on gastrointestinal biopsy specimens from 30 patients. Four clinical syndromes were identified: chronic diarrhea (36% of patients), choleralike disease (33%), transient diarrhea (15%), and relapsing illness (15%). A multivariate analysis of data for cases and controls revealed that acquiring cryptosporidiosis was associated with the presence of candidal esophagitis (odds ratio [OR], 2.53; P < .002) and Caucasian race (OR, 6.71; P = .0001) but not with sexual orientation. Cases had a significantly shorter duration of survival from the time of diagnosis than did controls (240 vs. 666 days, respectively; P = .0004), which was independent of sex, race, or or injection drug use. Antiretroviral use was protective against disease (OR, 0.072; P = .0001). All four clinical syndromes were represented among the histological data. There was no statistically significant correlation between histological intensity of infection and clinical severity of illness.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1058-4838
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
536-42
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9770154-AIDS-Related Opportunistic Infections,
pubmed-meshheading:9770154-Adult,
pubmed-meshheading:9770154-Aged,
pubmed-meshheading:9770154-Animals,
pubmed-meshheading:9770154-Case-Control Studies,
pubmed-meshheading:9770154-Cohort Studies,
pubmed-meshheading:9770154-Cryptosporidiosis,
pubmed-meshheading:9770154-Cryptosporidium,
pubmed-meshheading:9770154-Disease Progression,
pubmed-meshheading:9770154-Female,
pubmed-meshheading:9770154-Humans,
pubmed-meshheading:9770154-Logistic Models,
pubmed-meshheading:9770154-Male,
pubmed-meshheading:9770154-Middle Aged,
pubmed-meshheading:9770154-Survival Analysis
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Cryptosporidiosis in patients with AIDS: correlates of disease and survival.
|
| pubmed:affiliation |
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
|
| pubmed:publicationType |
Journal Article
|