| pubmed-article:9769338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0442874 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:9769338 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9769338 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9769338 | pubmed:dateCreated | 1998-11-12 | lld:pubmed |
| pubmed-article:9769338 | pubmed:abstractText | We hypothesized that sera from type 2 diabetic patients with neuropathy contains an autoimmune immunoglobulin that promotes complement-independent, calcium-dependent apoptosis in neuronal cell lines. Neuronal cells were cultured in the presence of complement-inactivated sera obtained from patients with type 2 diabetes with and without neuropathy and healthy adult control patients. Serum from diabetic patients with neuropathy was associated with a significantly greater induction of apoptosis, compared to serum from diabetic patients without neuropathy and controls. In the presence of calcium channel antagonists, induction of apoptosis was reduced by approximately 50%. Pretreatment of neuronal cells with serum from diabetic patients with neuropathy was associated with a significant increase in elevated K+-evoked cytosolic calcium concentration. Serum-induced enhancement in cytosolic calcium and calcium current density was blocked by treatment with trypsin and filtration of the serum using a 100,000-kd molecular weight filter. Treatment with an anti-human IgG antibody was associated with intense fluorescence on the surface of neuronal cells exposed to sera from patients with type 2 diabetes mellitus with neuropathy. We conclude that sera from type 2 diabetic patients with neuropathy contains an autoimmune immunoglobulin that induces complement-independent, calcium-dependent apoptosis in neuronal cells. | lld:pubmed |
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| pubmed-article:9769338 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9769338 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9769338 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9769338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9769338 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9769338 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9769338 | pubmed:author | pubmed-author:SrinivasanSS | lld:pubmed |
| pubmed-article:9769338 | pubmed:author | pubmed-author:ShengHH | lld:pubmed |
| pubmed-article:9769338 | pubmed:author | pubmed-author:WileyJ WJW | lld:pubmed |
| pubmed-article:9769338 | pubmed:author | pubmed-author:StevensM JMJ | lld:pubmed |
| pubmed-article:9769338 | pubmed:author | pubmed-author:HallK EKE | lld:pubmed |
| pubmed-article:9769338 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9769338 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9769338 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:9769338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9769338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9769338 | pubmed:pagination | 1454-62 | lld:pubmed |
| pubmed-article:9769338 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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