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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-11-13
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pubmed:abstractText |
We describe 12 cases of AIDS-related primary pulmonary lymphoma occurring between 1986 and 1996 in a large French cohort of HIV-infected patients. Diagnostic criteria were: (1) histologically proven lymphomatous pulmonary involvement; (2) absence of mediastinal and/or hilar adenopathy on chest radiography; (3) absence of extrathoracic lymphoma extension. All patients were severely immunodeficient at the time of diagnosis. All but one patient presented with B and/or nonspecific respiratory symptoms. Chest radiography showed one or more marginated nodule(s) or large mass. CT scan showed a cavitary lesion in five patients. No lymph node enlargement or specific pleural effusion was detected. Transthoracic needle biopsies were performed in 10 patients and avoided open-lung biopsy for the diagnosis of lymphoma in five patients. All but one of the primary pulmonary lymphoma were high-grade B-cell non-Hodgkin's lymphomas. Using antilatent membrane protein-1 antibodies and an Epstein-Barr-Virus-encoded RNA transcript-specific probe, latent EBV infection of tumor cells was demonstrated in every case. All but one of the patients received chemotherapy. The median survival time was 4 mo, and no patient was still alive at the cut-off date for this analysis. Progessive pulmonary lymphoma was the main cause of death, but infections were also frequent.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1073-449X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1221-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9769285-AIDS-Related Opportunistic Infections,
pubmed-meshheading:9769285-Adult,
pubmed-meshheading:9769285-Antigens, Viral,
pubmed-meshheading:9769285-Antineoplastic Agents,
pubmed-meshheading:9769285-Biopsy, Needle,
pubmed-meshheading:9769285-Cohort Studies,
pubmed-meshheading:9769285-Epstein-Barr Virus Infections,
pubmed-meshheading:9769285-Female,
pubmed-meshheading:9769285-Follow-Up Studies,
pubmed-meshheading:9769285-France,
pubmed-meshheading:9769285-HIV Infections,
pubmed-meshheading:9769285-Herpesvirus 4, Human,
pubmed-meshheading:9769285-Humans,
pubmed-meshheading:9769285-Lung Neoplasms,
pubmed-meshheading:9769285-Lymph Nodes,
pubmed-meshheading:9769285-Lymphoma, AIDS-Related,
pubmed-meshheading:9769285-Lymphoma, B-Cell,
pubmed-meshheading:9769285-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9769285-Male,
pubmed-meshheading:9769285-Middle Aged,
pubmed-meshheading:9769285-Pleural Effusion,
pubmed-meshheading:9769285-RNA, Viral,
pubmed-meshheading:9769285-Radiography, Thoracic,
pubmed-meshheading:9769285-Survival Rate,
pubmed-meshheading:9769285-Tomography, X-Ray Computed,
pubmed-meshheading:9769285-Viral Matrix Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
AIDS-related primary pulmonary lymphoma.
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pubmed:affiliation |
Services de Pneumologie et de Réanimation Respiratoire et Service d'Anatomie-Pathologique, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.
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pubmed:publicationType |
Journal Article
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