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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-10-22
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pubmed:abstractText |
In a retrospective analysis of 142 medullary thyroid carcinomas, four sporadic cases with an unusual histological and immunohistochemical appearance were found. Three cases (two males, one female) had very few calcitonin-positive tumour cells, while the fourth case (male) completely lacked calcitonin immunoreactivity at both mRNA and protein levels, whereas a variety of neuroendocrine markers were positive in at least 50% of tumour cells. The four tumours were completely devoid of carcinoembryonic antigen expression and of amyloid. Differential diagnosis and histogenetic considerations are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0945-6317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
433
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-15
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9769123-Adolescent,
pubmed-meshheading:9769123-Adult,
pubmed-meshheading:9769123-Aged,
pubmed-meshheading:9769123-Aged, 80 and over,
pubmed-meshheading:9769123-Calcitonin,
pubmed-meshheading:9769123-Carcinoma, Medullary,
pubmed-meshheading:9769123-Child,
pubmed-meshheading:9769123-Diagnosis, Differential,
pubmed-meshheading:9769123-Female,
pubmed-meshheading:9769123-Humans,
pubmed-meshheading:9769123-In Situ Hybridization,
pubmed-meshheading:9769123-Male,
pubmed-meshheading:9769123-Middle Aged,
pubmed-meshheading:9769123-RNA, Messenger,
pubmed-meshheading:9769123-RNA, Neoplasm,
pubmed-meshheading:9769123-Retrospective Studies,
pubmed-meshheading:9769123-Thyroid Neoplasms,
pubmed-meshheading:9769123-Tumor Markers, Biological
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pubmed:year |
1998
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pubmed:articleTitle |
"Atypical" medullary thyroid carcinoma with little or no calcitonin expression.
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pubmed:affiliation |
Department of Pathology, University of Munster/Westphalia, Münster, Germany. schmikw@uni-muenster.de
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pubmed:publicationType |
Journal Article
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