| pubmed-article:9768755 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0085110 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0034537 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0600499 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:9768755 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:9768755 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9768755 | pubmed:dateCreated | 1998-10-28 | lld:pubmed |
| pubmed-article:9768755 | pubmed:abstractText | The DNA-dependent protein kinase is a mammalian protein complex composed of Ku70, Ku80, and DNA-PKcs subunits that has been implicated in DNA double-strand break repair and V(D)J recombination. Here, by gene targeting, we have constructed a mouse with a disruption in the kinase domain of DNA-PKcs, generating an animal model completely devoid of DNA-PK activity. Our results demonstrate that DNA-PK activity is required for coding but not for signal join formation in mice. Although our DNA-PKcs defective mice closely resemble Scid mice, they differ by having elevated numbers of CD4+CD8+ thymocytes. This suggests that the Scid mice may not represent a null phenotype and may retain some residual DNA-PKcs function. | lld:pubmed |
| pubmed-article:9768755 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9768755 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9768755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9768755 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9768755 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9768755 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:GelbNN | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:PriestleyAA | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:JeggoP APA | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:JacksonS PSP | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:HerreraV LVL | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:TaccioliG EGE | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:BeamishH JHJ | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:XiangX HXH | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:AmatucciA GAG | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:Torres... | lld:pubmed |
| pubmed-article:9768755 | pubmed:author | pubmed-author:Marshak... | lld:pubmed |
| pubmed-article:9768755 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9768755 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9768755 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9768755 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9768755 | pubmed:pagination | 355-66 | lld:pubmed |
| pubmed-article:9768755 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9768755 | pubmed:meshHeading | pubmed-meshheading:9768755-... | lld:pubmed |
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| pubmed-article:9768755 | pubmed:meshHeading | pubmed-meshheading:9768755-... | lld:pubmed |
| pubmed-article:9768755 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9768755 | pubmed:articleTitle | Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. | lld:pubmed |
| pubmed-article:9768755 | pubmed:affiliation | Department of Microbiology, Boston University School of Medicine, Massachusetts 02118, USA. taccioli@bu.edu | lld:pubmed |
| pubmed-article:9768755 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9768755 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9768755 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19090 | entrezgene:pubmed | pubmed-article:9768755 | lld:entrezgene |
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