Linked Life Data

9768563

Source:http://linkedlifedata.com/resource/pubmed/id/9768563

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-12-16
pubmed:abstractText
Conditioned place preference (CPP) was employed to clarify the reinforcing and locomotor stimulating effects of several doses of cocaine and caffeine (0.32, 1.0, 3.2, 5.6, and 10.0 mg/kg) and to explore the possibility of additive effects between the two drugs. Additionally, the hypothesis that the reinforcing effects of psychostimulants are mediated by the same systems that control psychostimulant-induced locomotor activity was examined by conducting correlational studies between drug-induced locomotor activity and time spent in the drug-conditioned compartments. Several doses of cocaine (1.0, 3.0, 5.6, 10.0 mg/kg), and caffeine (0.32, 1.0, 3.2, 5.6, 10.0) were found to condition place preference and stimulate locomotor activity. A combination of low doses (0.32 mg/kg) of each drug appeared to be additive. A positive relationship between locomotor activity observed during conditioning and time spent in the conditioned compartment during testing was found for cocaine but not caffeine or the low-dose combination of cocaine and caffeine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Cocaine and caffeine: conditioned place preference, locomotor activity, and additivity.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.