Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
1999-2-1
|
| pubmed:abstractText |
The skin is responsible for forming a variety of epidermal structures that differ amongst vertebrates. In each case the specific structure (for example scale, feather or hair) arises from an epidermal placode as a result of epithelial-mesenchymal interactions with the underlying dermal mesenchyme. Expression of members of the Wnt, Hedgehog and bone morphogenetic protein families (Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4, respectively) in the epidermis correlates with the initiation of hair follicle formation. Further, their expression continues into either the epidermally derived hair matrix which forms the hair itself, or the dermal papilla which is responsible for induction of the hair matrix. To address the role of Shh in the hair follicle, we have examined Shh null mutant mice.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0960-9822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1058-68
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9768360-Animals,
pubmed-meshheading:9768360-Apoptosis,
pubmed-meshheading:9768360-Embryonic and Fetal Development,
pubmed-meshheading:9768360-Epidermis,
pubmed-meshheading:9768360-Exons,
pubmed-meshheading:9768360-Hair,
pubmed-meshheading:9768360-Hair Follicle,
pubmed-meshheading:9768360-Hedgehog Proteins,
pubmed-meshheading:9768360-In Situ Hybridization,
pubmed-meshheading:9768360-Ki-67 Antigen,
pubmed-meshheading:9768360-Mice,
pubmed-meshheading:9768360-Mice, Inbred C57BL,
pubmed-meshheading:9768360-Mice, Inbred CBA,
pubmed-meshheading:9768360-Mice, Knockout,
pubmed-meshheading:9768360-Morphogenesis,
pubmed-meshheading:9768360-Proteins,
pubmed-meshheading:9768360-Signal Transduction,
pubmed-meshheading:9768360-Skin Transplantation,
pubmed-meshheading:9768360-Trans-Activators
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Sonic hedgehog signaling is essential for hair development.
|
| pubmed:affiliation |
Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|