Linked Life Data

9767615

Source:http://linkedlifedata.com/resource/pubmed/id/9767615

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-12-1
pubmed:abstractText
The cisplatin-based conventional combination chemotherapy has been shown to prolong survival of patients with advanced non-small cell lung cancer (NSCLC), but the treatment effect is only modest and of little clinical significance. Several promising 'new-generation' anti-cancer drugs, such as taxanes, vinorelbine, gemcitabine and irinotecan, have offered both chance and challenge to develop effective chemotherapy against NSCLC. In Japan, large-scale phase III trials of cisplatin-irinotecan combination regimen vs. conventional chemotherapy have been conducted; patient accrual has been completed and the final results will be presented in a couple of years. Other new agents will also be available by the end of 1999, and it will be our important task to evaluate those drugs efficiently. The current standard treatment strategy against unresectable stage III NSCLC is chemo- radiotherapy. However, there remain many questions to be answered through well-designed clinical trials. Those include optimal timing and schedule of the chemoradiotherapy, dose and fractionation of radiation and best chemotherapy regimen. An important randomized trial of concurrent vs. sequential chemoradiotherapy has been conducted in Japan, which has suggested that the concurrent schedule has survival benefit. Many trials of concurrent chemoradiotherapy with the new agents are currently performed or planned, but potential toxicity of the concurrent chemoradiotherapy must be carefully evaluated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1323-7799
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-74
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Non-surgical treatment of advanced non-small cell lung cancer in Japan.
pubmed:affiliation
Department of Oncology, National Cancer Center Hospital, Tokyo, Japan.
pubmed:publicationType
Journal Article, Review