rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-12-31
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pubmed:abstractText |
The plasma concentration of 5-hydroxytryptamine (5-HT) in diabetic patients is higher than that in normal subjects. Since recent reports have demonstrated the presence of 5-HT2A receptor in glomerular mesangial cells, it is possible that 5-HT may be involved in the development of diabetic nephropathy through the 5-HT2A receptor in mesangial cells. Because expansion of the glomerular mesangial lesion is a characteristic feature of diabetic nephropathy, we examined the effect of 5-HT on the production of type IV collagen by human mesangial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Succinates,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/sarpogrelate
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0085-2538
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-92
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9767524-Cells, Cultured,
pubmed-meshheading:9767524-Collagen,
pubmed-meshheading:9767524-Diabetic Nephropathies,
pubmed-meshheading:9767524-Glomerular Mesangium,
pubmed-meshheading:9767524-Humans,
pubmed-meshheading:9767524-Ketanserin,
pubmed-meshheading:9767524-Kinetics,
pubmed-meshheading:9767524-Protein Kinase C,
pubmed-meshheading:9767524-RNA, Messenger,
pubmed-meshheading:9767524-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:9767524-Receptors, Serotonin,
pubmed-meshheading:9767524-Serotonin,
pubmed-meshheading:9767524-Serotonin Antagonists,
pubmed-meshheading:9767524-Succinates,
pubmed-meshheading:9767524-Transforming Growth Factor beta
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pubmed:year |
1998
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pubmed:articleTitle |
Serotonin enhances the production of type IV collagen by human mesangial cells.
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pubmed:affiliation |
Department of Metabolic Medicine, Kumamoto University School of Medicine, Honjo, Japan.
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pubmed:publicationType |
Journal Article
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