Linked Life Data

9767083

Source:http://linkedlifedata.com/resource/pubmed/id/9767083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-12-10
pubmed:abstractText
For several decades, cranial windows have been used to investigate questions relating to cerebral blood flow and its regulation. In general, these techniques have utilized either 'open' cranial windows for the direct observation of the intracranial vasculature, or 'closed' cranial windows in which the skull and dura are removed and replaced with a clear seal, such as a coverslip. Here we describe a method of studying blood flow responses elicited by the physiological stimulus of whisker movement while using a 'thinned skull' cranial window created over the rat whisker-barrel cortex. This method employing an automated whisker stimulator coupled with laser-Doppler flowmetry focused through the thinned skull cranial window, is less invasive than other cranial window techniques, and allows for the study of the effects of stimulation parameters and systemically administered compounds on whisker movement elicited blood flow responses. Automated whisker stimulation and data collection also allow for precise temporal averaging of laser-Doppler measured responses, leading to increased precision in determining the true shape of the evoked blood flow response pattern.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1385-299X
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Laser-Doppler flowmetry utilizing a thinned skull cranial window preparation and automated stimulation.
pubmed:affiliation
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.