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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-10-20
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pubmed:abstractText |
The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blocking the dopamine transporters. However, the levels of dopamine transporter blockade achieved by therapeutic doses of methylphenidate are not known. This study measured, for the first time, dopamine transporter occupancy by orally administered methylphenidate in the human brain and its rate of uptake in the brain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-953X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1325-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9766762-Administration, Oral,
pubmed-meshheading:9766762-Adult,
pubmed-meshheading:9766762-Animals,
pubmed-meshheading:9766762-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:9766762-Brain,
pubmed-meshheading:9766762-Brain Chemistry,
pubmed-meshheading:9766762-Carbon Radioisotopes,
pubmed-meshheading:9766762-Carrier Proteins,
pubmed-meshheading:9766762-Cocaine,
pubmed-meshheading:9766762-Dopamine,
pubmed-meshheading:9766762-Dopamine Antagonists,
pubmed-meshheading:9766762-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:9766762-Dose-Response Relationship, Drug,
pubmed-meshheading:9766762-Drug Administration Schedule,
pubmed-meshheading:9766762-Female,
pubmed-meshheading:9766762-Humans,
pubmed-meshheading:9766762-Male,
pubmed-meshheading:9766762-Membrane Glycoproteins,
pubmed-meshheading:9766762-Membrane Transport Proteins,
pubmed-meshheading:9766762-Methylphenidate,
pubmed-meshheading:9766762-Nerve Tissue Proteins,
pubmed-meshheading:9766762-Papio,
pubmed-meshheading:9766762-Tomography, Emission-Computed
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pubmed:year |
1998
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pubmed:articleTitle |
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
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pubmed:affiliation |
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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