| pubmed-article:9766631 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0014406 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C1420812 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0442821 | lld:lifeskim |
| pubmed-article:9766631 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9766631 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9766631 | pubmed:dateCreated | 1998-10-26 | lld:pubmed |
| pubmed-article:9766631 | pubmed:abstractText | CD134 (OX40) is involved in T cell costimulation and T cell-dependent antibody production. We show strongly increased T cell expression of CD134 in a model of T helper 2-mediated systemic autoimmunity, induced by HgCl2. Regulation of CD134 expression on CD4+ T cells was further studied in vitro, identifying CD134 as an early marker of T cell activation. CD134 expression could be induced by interleukin-4, but not by interferon-gamma or tumor necrosis factor-alpha. Effects of interleukin-4 and of phorbol 12-myristate 13-acetate on CD134 expression could be blocked by the protein kinase inhibitor staurosporin. Combination of these stimuli with ionomycin resulted in a strongly synergistic increase of CD134 expression, which was blocked by the calcineurin-inhibitor cyclosporin A. The results demonstrate the involvement of two synergistically acting pathways in induction of CD134 expression. Furthermore, they suggest a role for interleukin-4 in induction of CD134 expression in vivo. | lld:pubmed |
| pubmed-article:9766631 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9766631 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9766631 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9766631 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9766631 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9766631 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9766631 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:9766631 | pubmed:author | pubmed-author:RoosAA | lld:pubmed |
| pubmed-article:9766631 | pubmed:author | pubmed-author:WeeningJ JJJ | lld:pubmed |
| pubmed-article:9766631 | pubmed:author | pubmed-author:AtenJJ | lld:pubmed |
| pubmed-article:9766631 | pubmed:author | pubmed-author:Schilder-TolE... | lld:pubmed |
| pubmed-article:9766631 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9766631 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:9766631 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9766631 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9766631 | pubmed:pagination | 503-10 | lld:pubmed |
| pubmed-article:9766631 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:9766631 | pubmed:meshHeading | pubmed-meshheading:9766631-... | lld:pubmed |
| pubmed-article:9766631 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9766631 | pubmed:articleTitle | Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. | lld:pubmed |
| pubmed-article:9766631 | pubmed:affiliation | Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:9766631 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9766631 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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