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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-10-26
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pubmed:abstractText |
CD134 (OX40) is involved in T cell costimulation and T cell-dependent antibody production. We show strongly increased T cell expression of CD134 in a model of T helper 2-mediated systemic autoimmunity, induced by HgCl2. Regulation of CD134 expression on CD4+ T cells was further studied in vitro, identifying CD134 as an early marker of T cell activation. CD134 expression could be induced by interleukin-4, but not by interferon-gamma or tumor necrosis factor-alpha. Effects of interleukin-4 and of phorbol 12-myristate 13-acetate on CD134 expression could be blocked by the protein kinase inhibitor staurosporin. Combination of these stimuli with ionomycin resulted in a strongly synergistic increase of CD134 expression, which was blocked by the calcineurin-inhibitor cyclosporin A. The results demonstrate the involvement of two synergistically acting pathways in induction of CD134 expression. Furthermore, they suggest a role for interleukin-4 in induction of CD134 expression in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD27,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Mercuric Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
503-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9766631-Animals,
pubmed-meshheading:9766631-Antigens, CD27,
pubmed-meshheading:9766631-Autoimmunity,
pubmed-meshheading:9766631-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9766631-Cells, Cultured,
pubmed-meshheading:9766631-Cytokines,
pubmed-meshheading:9766631-Drug Synergism,
pubmed-meshheading:9766631-Female,
pubmed-meshheading:9766631-Gene Expression Regulation,
pubmed-meshheading:9766631-Interferon-gamma,
pubmed-meshheading:9766631-Interleukin-4,
pubmed-meshheading:9766631-Ionomycin,
pubmed-meshheading:9766631-Mercuric Chloride,
pubmed-meshheading:9766631-Protein Kinase Inhibitors,
pubmed-meshheading:9766631-Rats,
pubmed-meshheading:9766631-Rats, Inbred BN,
pubmed-meshheading:9766631-Receptors, Immunologic,
pubmed-meshheading:9766631-Receptors, OX40,
pubmed-meshheading:9766631-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9766631-Recombinant Proteins,
pubmed-meshheading:9766631-Staurosporine,
pubmed-meshheading:9766631-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9766631-Th2 Cells,
pubmed-meshheading:9766631-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment.
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pubmed:affiliation |
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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