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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1998-11-9
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pubmed:databankReference |
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pubmed:abstractText |
RP105 was originally discovered as a mouse B-cell surface molecule that transmits an activation signal. The signal leads to resistance against irradiation-induced apoptosis and massive B-cell proliferation. Recently, we found that mouse RP105 is associated with another molecule, MD-1. We have isolated here the human MD-1 cDNA. We show that human MD-1 is also associated with human RP105 and has an important role in cell surface expression of RP105. We also describe a monoclonal antibody (MoAb) that recognizes human RP105. Expression of RP105 is restricted to CD19(+) B cells. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Germinal center cells are either dull or negative. RP105 is thus a novel human B-cell marker that is preferentially expressed on mature B cells. Moreover, the anti-RP105 MoAb activates B cells, leading to increases in cell size, expression of a costimulatory molecule CD80, and DNA synthesis. The B-cell activation pathway using RP105 is conserved in humans.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/CD180 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Ly78 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ly86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 by The American Society of Hematology.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2815-22
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9763566-Amino Acid Sequence,
pubmed-meshheading:9763566-Animals,
pubmed-meshheading:9763566-Antibodies, Monoclonal,
pubmed-meshheading:9763566-Antigens, CD,
pubmed-meshheading:9763566-Antigens, Surface,
pubmed-meshheading:9763566-B-Lymphocytes,
pubmed-meshheading:9763566-Base Sequence,
pubmed-meshheading:9763566-Chickens,
pubmed-meshheading:9763566-Cloning, Molecular,
pubmed-meshheading:9763566-DNA, Complementary,
pubmed-meshheading:9763566-Germinal Center,
pubmed-meshheading:9763566-Humans,
pubmed-meshheading:9763566-Lymphocyte Activation,
pubmed-meshheading:9763566-Lymphoma,
pubmed-meshheading:9763566-Macromolecular Substances,
pubmed-meshheading:9763566-Membrane Glycoproteins,
pubmed-meshheading:9763566-Membrane Proteins,
pubmed-meshheading:9763566-Mice,
pubmed-meshheading:9763566-Mice, Inbred BALB C,
pubmed-meshheading:9763566-Molecular Sequence Data,
pubmed-meshheading:9763566-Palatine Tonsil,
pubmed-meshheading:9763566-Recombinant Fusion Proteins,
pubmed-meshheading:9763566-Sequence Alignment,
pubmed-meshheading:9763566-Sequence Homology, Amino Acid,
pubmed-meshheading:9763566-Signal Transduction,
pubmed-meshheading:9763566-Species Specificity,
pubmed-meshheading:9763566-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
RP105 is associated with MD-1 and transmits an activation signal in human B cells.
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pubmed:affiliation |
Department of Immunology and the Division of Dermatology in the Department of Internal Medicine, Saga Medical School, Saga, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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