Linked Life Data

9761588

Source:http://linkedlifedata.com/resource/pubmed/id/9761588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1998-12-17
pubmed:abstractText
ct/ct mice are a mutation of the CBA strain with a high incidence of spina bifida (SB). Because humans with SB can exhibit abnormal behavior, we compared ct/ct and CBA mice using a neurologic assessment tool. ct/ct mice are more active and engage in more climbing, and stereotypical and compulsive behavior. When stimulated during cage removal ct/ct mice react more vigorously. ct/ct mice react more vigorously to a novel stimulus, and will vigorously search for a stable surface during visual placement. In the open field ct/ct mice crossed more lines and reared more than CBA. ct/ct mice demonstrated deficient performance in a modified Morris water maze. No differences were noted for other behaviors tested. The results argue that the mutation that produces SB in ct/ct mice also alters brain structure or chemistry. This is consistent with the findings in humans where SB can produce a variety of behavioral anomalies, most notably hyperactivity, attentional disorders, learning disabilities, and developmental lags.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0892-0362
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-10
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:articleTitle
Comparison of the behavior of the curly tail and CBA mouse on a neurologic scale.
pubmed:affiliation
Department of Psychology, University of Nebraska at Kearney, 68849, USA. briner@platte.unk.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't