Linked Life Data

9761369

Source:http://linkedlifedata.com/resource/pubmed/id/9761369

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-12-11
pubmed:abstractText
A family of caspases has been implicated as an effector in various forms of apoptosis. The present study investigated whether this family of proteases is involved in the induction of intrathymic clonal deletion in comparison with apoptosis induced in the thymus by various signals. Potent apoptosis of thymocytes was induced in fetal thymus organ cultures (FTOC) when FTOC were treated with glucocorticoid, radiation, and anti-CD3 monoclonal antibody (mAb). As a model of negative selection based on apoptotic clonal deletion, the elimination of Vbeta8-expressing thymocytes was induced by inoculating Staphylococcal enterotoxin B (SEB) into FTOC. Addition of a peptide-based caspase inhibitor resulted in the protection of thymocytes from apoptosis induced by glucocorticoid, radiation, and anti-CD3 mAb. In contrast, the same treatment failed to prevent clonal deletion of Vbeta8high thymocytes. These results suggest that different pathways of cell death operate in the thymus that may be distinguished depending on the caspase/protease utilized in each pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture.
pubmed:affiliation
Biomedical Research Center, Osaka University Medical School, Suita, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't