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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1998-10-28
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pubmed:abstractText |
Administration of Cu/Zn superoxide dismutase (SOD) without catalase fails to alleviate myocardial stunning, but extracellular SOD (Ec-SOD) may be more effective because it binds to heparan sulfate proteoglycans on the cellular glycocalyx. We therefore used in vivo gene transfer to increase systemic levels of Ec-SOD and determined whether this gene therapy protects against myocardial stunning. METHODS and
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1438-48
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9760299-Adenoviruses, Human,
pubmed-meshheading:9760299-Animals,
pubmed-meshheading:9760299-Antioxidants,
pubmed-meshheading:9760299-Consciousness,
pubmed-meshheading:9760299-Defective Viruses,
pubmed-meshheading:9760299-Dextran Sulfate,
pubmed-meshheading:9760299-Extracellular Space,
pubmed-meshheading:9760299-Gene Therapy,
pubmed-meshheading:9760299-Genetic Vectors,
pubmed-meshheading:9760299-Glycocalyx,
pubmed-meshheading:9760299-Heparan Sulfate Proteoglycans,
pubmed-meshheading:9760299-Humans,
pubmed-meshheading:9760299-Liver,
pubmed-meshheading:9760299-Male,
pubmed-meshheading:9760299-Myocardial Reperfusion Injury,
pubmed-meshheading:9760299-Myocardial Stunning,
pubmed-meshheading:9760299-Pilot Projects,
pubmed-meshheading:9760299-Rabbits,
pubmed-meshheading:9760299-Recombinant Fusion Proteins,
pubmed-meshheading:9760299-Superoxide Dismutase
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pubmed:year |
1998
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pubmed:articleTitle |
Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbits.
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pubmed:affiliation |
Molecular Cardiology Unit and the Experimental Research Laboratory of the Division of Cardiology, University of Louisville, KY, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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