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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1998-12-10
|
| pubmed:abstractText |
Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [3H]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V.
|
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
807
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
177-81
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9757030-Animals,
pubmed-meshheading:9757030-Basal Ganglia,
pubmed-meshheading:9757030-Brain,
pubmed-meshheading:9757030-Brain Mapping,
pubmed-meshheading:9757030-Caudate Nucleus,
pubmed-meshheading:9757030-Cerebral Cortex,
pubmed-meshheading:9757030-Disease Models, Animal,
pubmed-meshheading:9757030-Fatty Acids,
pubmed-meshheading:9757030-Functional Laterality,
pubmed-meshheading:9757030-Globus Pallidus,
pubmed-meshheading:9757030-Male,
pubmed-meshheading:9757030-Parkinson Disease, Secondary,
pubmed-meshheading:9757030-Phospholipases A,
pubmed-meshheading:9757030-Phospholipases A2,
pubmed-meshheading:9757030-Putamen,
pubmed-meshheading:9757030-Rats,
pubmed-meshheading:9757030-Rats, Sprague-Dawley,
pubmed-meshheading:9757030-Signal Transduction
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.
|
| pubmed:affiliation |
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-1582, USA.
|
| pubmed:publicationType |
Journal Article
|