Linked Life Data

9756360

Source:http://linkedlifedata.com/resource/pubmed/id/9756360

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pubmed-article:9756360pubmed:abstractTextThe psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and whole-cell recordings from isolated NAc neurons. In NAc slices, AMPH inhibited the field potentials. The inhibition increased when the NAc neurons were depolarized with higher extracellular K+ or when the field potentials were evoked at a higher rate. In isolated NAc neurons, AMPH inhibited the Na+ currents. The inhibition increased when Na+ currents were activated from more depolarized holding potentials or were activated more frequently. The voltage- and use-dependent inhibition of field potentials and Na+ currents by AMPH suggests a similar mechanism of AMPH action with local anesthetics and antiarrhythmic drugs.lld:pubmed
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pubmed-article:9756360pubmed:authorpubmed-author:LinJ YJYlld:pubmed
pubmed-article:9756360pubmed:authorpubmed-author:HuangR CRClld:pubmed
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pubmed-article:9756360pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9756360pubmed:year1998lld:pubmed
pubmed-article:9756360pubmed:articleTitleVoltage- and use-dependent inhibition by amphetamine of field potentials and Na+ current in rat nucleus accumbens neurons.lld:pubmed
pubmed-article:9756360pubmed:affiliationDepartment of Physiology, Chang Gung University School of Medicine, Tao-Yuan, Taiwan. rongchi@cguaplo.cgu.edu.twlld:pubmed
pubmed-article:9756360pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9756360pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed