Linked Life Data

9756360

Source:http://linkedlifedata.com/resource/pubmed/id/9756360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-11-25
pubmed:abstractText
The psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and whole-cell recordings from isolated NAc neurons. In NAc slices, AMPH inhibited the field potentials. The inhibition increased when the NAc neurons were depolarized with higher extracellular K+ or when the field potentials were evoked at a higher rate. In isolated NAc neurons, AMPH inhibited the Na+ currents. The inhibition increased when Na+ currents were activated from more depolarized holding potentials or were activated more frequently. The voltage- and use-dependent inhibition of field potentials and Na+ currents by AMPH suggests a similar mechanism of AMPH action with local anesthetics and antiarrhythmic drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
252
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Voltage- and use-dependent inhibition by amphetamine of field potentials and Na+ current in rat nucleus accumbens neurons.
pubmed:affiliation
Department of Physiology, Chang Gung University School of Medicine, Tao-Yuan, Taiwan. rongchi@cguaplo.cgu.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't