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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1998-11-23
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pubmed:abstractText |
Studies with tumor necrosis factor p55 receptor- and interleukin-6 (IL-6)-deficient mice have shown that IL-6 is required for hepatocyte proliferation and reconstitution of the liver mass after partial hepatectomy. The biological activities of IL-6 are potentiated when this cytokine binds soluble forms of its specific receptor subunit (sIL-6R) and the resulting complex interacts with the transmembrane signaling chain gp130. We show here that double transgenic mice expressing high levels of both human IL-6 and sIL-6R under the control of liver-specific promoters spontaneously develop nodules of hepatocellular hyperplasia around periportal spaces and present signs of sustained hepatocyte proliferation. The resulting picture is identical to that of human nodular regenerative hyperplasia, a condition frequently associated with immunological and myeloproliferative disorders. In high expressors, hyperplastic lesions progress with time into discrete liver adenomas. These data strongly suggest that the IL-6/sIL-6R complex is both a primary stimulus to hepatocyte proliferation and a pathogenic factor of hepatocellular transformation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-1381393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-1545125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2035739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2127356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2189821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2261637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2350785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2505958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-2529343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-3044605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-669201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-7203455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-7513204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-7535932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-7632928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-7943321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8076766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8182142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8436181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8458373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8547132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8639436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8666898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-8910279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9034153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9037072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9075932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9082986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9085170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9233646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9505140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9755159-9708822
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0261-4189
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pubmed:author |
pubmed-author:CilibertiAA,
pubmed-author:Della RoccaCC,
pubmed-author:Di CarloEE,
pubmed-author:LUCC,
pubmed-author:LazzaroDD,
pubmed-author:MaioneDD,
pubmed-author:ModestiAA,
pubmed-author:MusianiPP,
pubmed-author:PetersMM,
pubmed-author:Rose-JohnSS,
pubmed-author:SavinoRR,
pubmed-author:TaubRR,
pubmed-author:TripodiMM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5588-97
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9755159-Adenoma,
pubmed-meshheading:9755159-Animals,
pubmed-meshheading:9755159-DNA-Binding Proteins,
pubmed-meshheading:9755159-Endothelium, Vascular,
pubmed-meshheading:9755159-Gene Expression Regulation,
pubmed-meshheading:9755159-Haptoglobins,
pubmed-meshheading:9755159-Hyperplasia,
pubmed-meshheading:9755159-Interleukin-6,
pubmed-meshheading:9755159-Liver,
pubmed-meshheading:9755159-Liver Neoplasms,
pubmed-meshheading:9755159-Liver Regeneration,
pubmed-meshheading:9755159-Mice,
pubmed-meshheading:9755159-Mice, Transgenic,
pubmed-meshheading:9755159-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:9755159-Receptors, Interleukin-6,
pubmed-meshheading:9755159-STAT3 Transcription Factor,
pubmed-meshheading:9755159-Solubility,
pubmed-meshheading:9755159-Trans-Activators
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pubmed:year |
1998
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pubmed:articleTitle |
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.
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pubmed:affiliation |
Istituto Ricerche di Biologia Molecolare (IRBM) P.Angeletti, Via Pontina Km 30.600, 00400 Pomezia, Rome.
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