| pubmed-article:9755059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9755059 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9755059 | pubmed:issue | 4 Pt 1 | lld:pubmed |
| pubmed-article:9755059 | pubmed:dateCreated | 1998-11-23 | lld:pubmed |
| pubmed-article:9755059 | pubmed:abstractText | Toxins convert the hepatocellular response to tumor necrosis factor-alpha (TNF-alpha) stimulation from proliferation to cell death, suggesting that hepatotoxins somehow sensitize hepatocytes to TNF-alpha toxicity. Because nuclear factor-kappaB (NF-kappaB) activation confers resistance to TNF-alpha cytotoxicity in nonhepatic cells, the possibility that toxin-induced sensitization to TNF-alpha killing results from inhibition of NF-kappaB-dependent gene expression was examined in the RALA rat hepatocyte cell line sensitized to TNF-alpha cytotoxicity by actinomycin D (ActD). ActD did not affect TNF-alpha-induced hepatocyte NF-kappaB activation but decreased NF-kappaB-dependent gene expression. Expression of an IkappaB superrepressor rendered RALA hepatocytes sensitive to TNF-alpha-induced apoptosis in the absence of ActD. Apoptosis was blocked by caspase inhibitors, and TNF-alpha treatment led to activation of caspase-2, caspase-3, and caspase-8 only when NF-kappaB activation was blocked. Although apoptosis was blocked by the NF-kappaB-dependent factor nitric oxide (NO), inhibition of endogenous NO production did not sensitize cells to TNF-alpha-induced cytotoxicity. Thus NF-kappaB activation is the critical intracellular signal that determines whether TNF-alpha stimulates hepatocyte proliferation or apoptosis. Although exogenous NO blocks RALA hepatocyte TNF-alpha cytotoxicity, endogenous production of NO is not the mechanism by which NF-kappaB activation inhibits this death pathway. | lld:pubmed |
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| pubmed-article:9755059 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9755059 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9755059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9755059 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9755059 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:JonesB EBE | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:SrinivasanAA | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:KitsisR NRN | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:CzajaM JMJ | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:BrennerD ADA | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:XuYY | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:IimuroYY | lld:pubmed |
| pubmed-article:9755059 | pubmed:author | pubmed-author:BialikSS | lld:pubmed |
| pubmed-article:9755059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9755059 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:9755059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9755059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9755059 | pubmed:pagination | C1058-66 | lld:pubmed |
| pubmed-article:9755059 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9755059 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9755059 | pubmed:articleTitle | NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. | lld:pubmed |
| pubmed-article:9755059 | pubmed:affiliation | Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. | lld:pubmed |
| pubmed-article:9755059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9755059 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9755059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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