Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-12-29
|
| pubmed:abstractText |
The mammalian hippocampus has been the focus of several neurobiology studies because of its important behavioral function and because long-term potentiation (LTP) is a prominent feature of this brain region. Converging evidence suggests that hippocampal function is associated with learning multiple relationships of environmental cues. In this paper a novel behavioral test procedure is introduced, a modified T-maze continuous alternation task (T-CAT), that may serve as a simple, automatable, and quick test of hippocampal function in addition to the frequently applied water maze and fear conditioning paradigms. A comparison is made between mice (strain C57BL/6) with ibotenic acid lesioned or vehicle injected hippocampus, two transgenic strains (on CD1 background) overexpressing a calcium binding protein, S100beta, and inbred (C57BL/6, DBA/2, 129/SV and 129/SVEV) and outbred (CD1) strains of mice. This study shows that hippocampal lesioning led to a significant impairment in T-CAT. Furthermore, overexpression of S100beta, which impairs hippocampal LTP, also led to an impairment demonstrating that T-CAT is sensitive to detect hippocampal dysfunction. Analysis of the mouse strains revealed that C57BL/6 and CD1 mice performed well in T-CAT, whereas 129/SV, 129/SVEV and DBA/2 were significantly impaired, a finding that underscores the importance of strain differences in pharmacological or single gene manipulation studies of hippocampal function in mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0166-4328
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
91-101
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9754881-Animals,
pubmed-meshheading:9754881-Cues,
pubmed-meshheading:9754881-Excitatory Amino Acid Agonists,
pubmed-meshheading:9754881-Hippocampus,
pubmed-meshheading:9754881-Ibotenic Acid,
pubmed-meshheading:9754881-Male,
pubmed-meshheading:9754881-Maze Learning,
pubmed-meshheading:9754881-Mice,
pubmed-meshheading:9754881-Mice, Inbred C57BL,
pubmed-meshheading:9754881-Mice, Inbred DBA,
pubmed-meshheading:9754881-Mice, Neurologic Mutants,
pubmed-meshheading:9754881-S100 Proteins,
pubmed-meshheading:9754881-Species Specificity
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
A new continuous alternation task in T-maze detects hippocampal dysfunction in mice. A strain comparison and lesion study.
|
| pubmed:affiliation |
Genentech, Inc., Neuroscience Department, South San Francisco, CA 94080, USA. gerlai@gene.com
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|