Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-10-21
|
| pubmed:abstractText |
Parkinson's disease (PD), a disorder of unknown etiology, is associated with the degeneration of dopaminergic neurons in nigro-striatal pathways. MPTP, a meperidine analog, causes parkinsonism in human and nonhuman primates. MPP+, the active metabolite of MPTP, inhibits the activity of respiratory chain complex I. In patients with PD, a reduced complex I activity was found in substantia nigra, skeletal muscle, and platelets. Because complex I is partially encoded by the mitochondrial genome, several studies have searched for mitochondrial (mt) DNA abnormalities in patients with PD. Our aim was to answer the following questions: (1) are there some abnormalities of mtDNA in PD? (2) if there are some, what are these abnormalities? and (3) what is the pathogenic role of these abnormalities? METHODS: The literature review was performed using Medline [National Library of Medicine, Washington] and Current Contents [Institute for Scientific Information, Philadelphia] databases. Periods screened were 1966-March, 1998 (Medline) and March 17, 1997-March 9, 1998 (Current Contents). Keywords were: "Parkinson" or "Parkinson's", and "mitochondrial DNA" or "mtDNA". We limited our research to articles in English and French. RESULTS: Medline search provided 59 articles. Current Contents search provided 22 articles. Twelve articles were found in both databases. Thirty-eight of the 69 articles were either reviews about mitochondrial diseases (19 articles) or original articles not related to mtDNA (19 articles). Our final selection included the remaining 31 articles.
|
| pubmed:language |
fre
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0395-501X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
261-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9754389-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:9754389-Animals,
pubmed-meshheading:9754389-Brain,
pubmed-meshheading:9754389-DNA, Mitochondrial,
pubmed-meshheading:9754389-Humans,
pubmed-meshheading:9754389-MEDLINE,
pubmed-meshheading:9754389-Mutation,
pubmed-meshheading:9754389-National Library of Medicine (U.S.),
pubmed-meshheading:9754389-Parkinson Disease,
pubmed-meshheading:9754389-Parkinson Disease, Secondary,
pubmed-meshheading:9754389-Primates,
pubmed-meshheading:9754389-United States
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
[Mitochondrial DNA and Parkinson disease. Methodologic review].
|
| pubmed:affiliation |
Groupe d'Etudes et de Recherches sur le Muscle et le Nerf, EA 2347, Université Paris XII, Faculté de Médecine, Créteil.
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Review
|