Linked Life Data

9753920

Source:http://linkedlifedata.com/resource/pubmed/id/9753920

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-10-29
pubmed:abstractText
To determine whether 123I-MIBG (MIBG) scintigraphy is useful for predicting the effect of beta-blocker therapy in patients with dilated cardiomyopathy (DCM), we studied MIBG scintigraphy in 11 controls and 9 patients with DCM before starting beta-blocker therapy. First, initial and delayed heart-to-mediastinum ratios (H/M ratio) of MIBG activity in patients with DCM were significantly lower than those in 11 controls, respectively (initial H/M; 1.8 +/- 0.3 vs. 2.1 +/- 0.3, p < 0.02, delayed H/M; 1.6 +/- 0.3 vs. 2.4 +/- 0.2, p < 0.0001), and MIBG washout rate from the heart was significantly higher in patients than in controls (washout rate; 33 +/- 7% vs. 22 +/- 4%, p < 0.0005). Second, beta-blocker therapy improved LVEF in 7 patients (improved group), while it resulted in deterioration of heart failure, followed by death in 2 patients (deteriorated group). Although initial and delayed H/M ratios in the improved group were not significantly different from those in the deteriorated group, respectively, MIBG washout rate was significantly higher in the deteriorated group than in the improved group (45 +/- 8% vs. 30 +/- 3%, p = 0.04). Our study suggests that DCM patients with markedly rapid MIBG clearance may be deteriorated by beta-blocker therapy. In contrast, there were no differences in LVEF and plasma norepinephrine between improved and deteriorated groups. In conclusion, 123I-MIBG scintigraphy is useful for predicting the effects of beta-blocker therapy in patients with DCM.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-7854
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
413-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[Usefulness of 123I-MIBG scintigraphy for prediction of effect of beta-blocker therapy in dilated cardiomyopathy].
pubmed:affiliation
Department of Internal Medicine, Hamamatsu Red Cross Hospital.
pubmed:publicationType
Journal Article, English Abstract