Linked Life Data

9753585

Source:http://linkedlifedata.com/resource/pubmed/id/9753585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-11-10
pubmed:abstractText
Classical studies have demonstrated a role for protein synthesis in long-term memory. The focus of our research is to identify the proteins that are essential for memory and to discover how they contribute to activity-dependent neuronal plasticity. We have developed whole-animal models that maximize the induction of activity-dependent genes and have used differential cloning techniques to identify a set of novel, neuronal immediate-early genes (IEGs). Neuronal IEGs encode transcription factors, cytoskeletal proteins, growth factors, metabolic enzymes, and proteins involved in signal transduction. The biochemical and cell biological properties of these molecules provide important insights into mechanisms that contribute to neuronal plasticity. Recently, we identified a subset of IEGs that appear to function at the synapse. These molecules extend the functional repertoire of IEGs and may provide insight into how IEGs can contribute to synapse-specific plasticity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1074-7427
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Academic Press.
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-43
pubmed:dateRevised
2007-10-17
pubmed:meshHeading
pubmed:articleTitle
Immediate-early genes and synaptic function.
pubmed:affiliation
Department of Neuroscience, The Johns Hopkins School of Medicine, 905 Hunterian Building, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review