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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1998-10-9
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pubmed:abstractText |
The differential urinary excretion of orally administered lactulose and mannitol is used to evaluate intestinal permeability. This test usually involves a 5- to 6-hr urine collection. We hypothesized that a shorter collection time would give an equivalent result. Forty-three patients with a variety of gastrointestinal symptoms and diagnoses (group 1) and 42 patients with Crohn's disease (group 2) had a standard lactulose/mannitol permeability test. The lactulose and mannitol urinary excretion was calculated using the first urine (group 1) or the 1-hr and 2-hr urine (group 2) and was compared to the values calculated from the routine 5- or 6-hr collection. Lactulose excretion kinetics, expressed as the percent of the total urinary excretion within a given time period, were as follows: 21% in first hour (group 2), 29% in second hour (group 2), and 46% in first 2.5 hr (group 1). Mannitol urinary excretion kinetics were 16%, 31%, and 44%, respectively. The lactulose/mannitol ratio based on a standard urine collection correlated well with the ratio based on just the first urine produced by the patient (R2 = 0.94; P < 0.001; group 1) and the 2-hr urine (R2 = 0.464; P < 0.001; group 2). Future use of the lactulose/mannitol ratio to assess intestinal permeability may be able to be simplified by shortening the urine collection time.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0163-2116
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1946-50
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9753256-Administration, Oral,
pubmed-meshheading:9753256-Adult,
pubmed-meshheading:9753256-Aged,
pubmed-meshheading:9753256-Female,
pubmed-meshheading:9753256-Humans,
pubmed-meshheading:9753256-Intestinal Absorption,
pubmed-meshheading:9753256-Intestinal Mucosa,
pubmed-meshheading:9753256-Intestine, Small,
pubmed-meshheading:9753256-Lactulose,
pubmed-meshheading:9753256-Male,
pubmed-meshheading:9753256-Mannitol,
pubmed-meshheading:9753256-Middle Aged,
pubmed-meshheading:9753256-Specimen Handling,
pubmed-meshheading:9753256-Time Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Assessment of intestinal permeability with a two-hour urine collection.
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pubmed:affiliation |
Department of Medicine, Ben Taub Hospital, Baylor College of Medicine, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article
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