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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001758,
umls-concept:C0001924,
umls-concept:C0003015,
umls-concept:C0005823,
umls-concept:C0030705,
umls-concept:C0076891,
umls-concept:C0221102,
umls-concept:C0439841,
umls-concept:C0439849,
umls-concept:C0857121,
umls-concept:C1442488,
umls-concept:C1524119,
umls-concept:C1547135,
umls-concept:C1547139,
umls-concept:C1561560,
umls-concept:C1561561
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| pubmed:issue |
9
|
| pubmed:dateCreated |
1998-11-24
|
| pubmed:abstractText |
The aim of the present study was to examine the relationships between ambulatory blood pressure (ABPM) and urinary albumin excretion (UAE) in diabetic (non-insulin dependent [NIDDM] and insulin-dependent [IDDM]) hypertensives at baseline and after treatment by an angiotensin converting enzyme (ACE) inhibitor. After a 3-week placebo period, patients were treated for 16 weeks with trandolapril, 2 to 4 mg/day. The UAE and blood pressure (mercury sphygmomanometer and 24-h ABPM) were measured at baseline and repeated on trandolapril. Predictive factors of abnormal UAE (24-h UAE > or = 30 mg) were determined using univariate and multivariate analysis (logistic regression). Predictors of UAE decrease were also searched. One hundred seventy-one patients entered the analysis. Baseline office BP was 164+/-14 / 97+/-6 mm Hg and 24-h BP was 142+/-17 / 83+/-10 mm Hg. Seventy-four patients (43%) had UAE > or = 30 mg. Independent risk factors for abnormal UAE were nighttime diastolic BP (odds ratio [OR] = 4.1, confidence interval [CI] = 2.0 to 8.6, P = .0001), diabetes duration (OR = 2.4, CI = 1.1 to 5.0, P = .025), and presence of retinopathy (OR = 3.2, CI = 1.0 to 10.0, P = .047). Conversely, office BP level was not significantly related to UAE. On treatment, office BP levels decreased to 143+/-13 / 82+/-8 mm Hg (P < .0001) and 24-h BP levels to 134+/-17 / 78+/-9 mm Hg (P < .0001). In the abnormal UAE group, UAE significantly decreased from 76 to 50 mg/day (P = .006). After treatment, independent predictive factors of abnormal UAE were: on-drug fasting plasma glucose (OR = 3.5, CI = 1.7 to 7.4, P = .0009) and on-drug nighttime diastolic BP (OR = 3.5, CI = 1.7 to 7.4, P = .001). The only predictor of UAE decrease was a 24-h systolic BP decrease (OR = 2.3, CI = 1.3 to 4.3, P = .007). We conclude that in diabetic hypertensives with abnormal UAE, trandolapril exhibited a sustained 24-h antihypertensive effect and provided a consistent reduction of microalbuminuria. This study confirmed the superiority of ABPM over clinical BP to predict target organ damage.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0895-7061
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1065-73
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| pubmed:dateRevised |
2009-2-24
|
| pubmed:meshHeading |
pubmed-meshheading:9752891-Albuminuria,
pubmed-meshheading:9752891-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:9752891-Blood Pressure,
pubmed-meshheading:9752891-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:9752891-Diabetes Mellitus, Type 1,
pubmed-meshheading:9752891-Diabetes Mellitus, Type 2,
pubmed-meshheading:9752891-Humans,
pubmed-meshheading:9752891-Hypertension,
pubmed-meshheading:9752891-Indoles
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Ambulatory blood pressure and urinary albumin excretion in diabetic (non-insulin-dependent and insulin-dependent) hypertensive patients: relationships at baseline and after treatment by the angiotensin converting enzyme inhibitor trandolapril.
|
| pubmed:affiliation |
Hôpital Bégin, Saint Mandé, France.
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| pubmed:publicationType |
Journal Article
|