|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1998-10-1
|
|
pubmed:abstractText |
The interaction between the estrogen receptor and a variety of flavonoids was studied in the presence or absence of estradiol using a stably-transfected human breast cancer cell line (MVLN). On the other hand, flavonoids were evaluated for their effects on proliferation in estrogen-dependent (MCF-7) and independent (MDA-MB231) human breast cancer cells. We established a relationship structure-activity and determined regions and/or substituents essential for estrogenic or antiestrogenic activities. In contrast, we did not find the same relationship for cell proliferation. Among all flavonoids used, only 7-methoxyflavanone and 7,8-dihydroxyflavone at high concentrations (50 microM) possess antiestrogenic and antiproliferative activities. These results suggest that two hydroxyls (in positions 7 and 8) or 7-methoxy substituents are essential for the antiestrogenic activity of flavonoids. However, it seems that flavonoids at high concentrations exert their antiproliferative activity through other estrogen receptor-independent mechanisms.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0304-3835
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
14
|
|
pubmed:volume |
130
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
209-16
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9751276-Antineoplastic Agents, Hormonal,
pubmed-meshheading:9751276-Breast Neoplasms,
pubmed-meshheading:9751276-Cell Division,
pubmed-meshheading:9751276-Dose-Response Relationship, Drug,
pubmed-meshheading:9751276-Drug Screening Assays, Antitumor,
pubmed-meshheading:9751276-Enzyme Induction,
pubmed-meshheading:9751276-Estrogen Antagonists,
pubmed-meshheading:9751276-Female,
pubmed-meshheading:9751276-Flavonoids,
pubmed-meshheading:9751276-Flavonols,
pubmed-meshheading:9751276-Genes, Reporter,
pubmed-meshheading:9751276-Genistein,
pubmed-meshheading:9751276-Humans,
pubmed-meshheading:9751276-Luciferases,
pubmed-meshheading:9751276-Receptors, Estrogen,
pubmed-meshheading:9751276-Tamoxifen,
pubmed-meshheading:9751276-Tumor Cells, Cultured
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids.
|
|
pubmed:affiliation |
UPRES EA 1085, Laboratoire de Biochimie, Faculté de Pharmacie, Limoges, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
