Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-10-28
|
| pubmed:abstractText |
In order to identify genes that may underlie the maintenance of long-term potentiation (LTP) at perforant path synapses, complementary DNA libraries were synthesised from dentate gyrus total RNA extracts prepared 48 h after the induction of LTP and from control dentate gyrus extracts. Through differential screening of the LTP library we have identified the mitochondrial 12S rRNA (mt12SrRNA) as a transcript that was elevated at this late time. Northern blot analyses showed that the elevation in mt12SrRNA expression began around 8 h and persisted for at least 2 weeks post-tetanus. We then examined the expression patterns of other mitochondrially-encoded genes and demonstrated a similar elevation in their expression. mt12SrRNA levels were also elevated in other hippocampal regions, including areas CA3 and CA1 and were elevated following low-frequency stimulation or in the presence of an N-methyl-D-aspartate receptor antagonist where induction of LTP was precluded. Taken together, these observations suggest that a long-lasting up-regulation of energy production may be triggered by synaptic activity and this activity need not be of sufficient strength to induce LTP, but may be related to the induction of a metaplastic state.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, ribosomal, 12S,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0169-328X
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 1998 Elsevier Science B.V.
|
| pubmed:issnType |
Print
|
| pubmed:day |
18
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
50-6
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9748499-Animals,
pubmed-meshheading:9748499-DNA, Complementary,
pubmed-meshheading:9748499-Dentate Gyrus,
pubmed-meshheading:9748499-Gene Expression,
pubmed-meshheading:9748499-Gene Library,
pubmed-meshheading:9748499-Long-Term Potentiation,
pubmed-meshheading:9748499-Male,
pubmed-meshheading:9748499-Memory,
pubmed-meshheading:9748499-Mitochondria,
pubmed-meshheading:9748499-Neurons,
pubmed-meshheading:9748499-Perforant Pathway,
pubmed-meshheading:9748499-RNA,
pubmed-meshheading:9748499-RNA, Messenger,
pubmed-meshheading:9748499-RNA, Ribosomal,
pubmed-meshheading:9748499-Rats,
pubmed-meshheading:9748499-Rats, Sprague-Dawley,
pubmed-meshheading:9748499-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9748499-Synapses,
pubmed-meshheading:9748499-Transcriptional Activation
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synaptic activity-dependent modulation of mitochondrial gene expression in the rat hippocampus.
|
| pubmed:affiliation |
Department of Biochemistry and Centre for Gene Research, University of Otago, P.O. Box 56, Dunedin, New Zealand.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|